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p-MPPI hydrochloride
CAS No. 220643-77-6
p-MPPI hydrochloride ( —— )
Catalog No. M22028 CAS No. 220643-77-6
p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 77 | In Stock |
|
| 25MG | 133 | In Stock |
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| 50MG | 222 | In Stock |
|
| 100MG | 352 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Namep-MPPI hydrochloride
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NoteResearch use only, not for human use.
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Brief Descriptionp-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects.
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Descriptionp-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects. pre-treatment with p-MPPI (5 mg/kg intraperitoneal (i.p.)) 30 min before 8-OH-DPAT (0.375 mg/kg subcutaneously (s.c.)) reduced the effect of 8-OH-DPAT on waking and REM sleep.?Also, p-MPPI (5 and 10 mg/kg i.p.) reduced the effect of 8-OH-DPAT on locomotion and partially or completely antagonized hindlimb abduction and flat body posture.?No overt behavioural change was produced by p-MPPI alone.?Thus, p-MPPI behaved as a true 5-HT(1A) antagonist.
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Synonyms——
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT1A
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Research Area——
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Indication——
Chemical Information
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CAS Number220643-77-6
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Formula Weight578.87
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Molecular FormulaC25H28ClIN4O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCl.COC1=CC=CC=C1N1CCN(CCN(C(=O)C2=CC=C(I)C=C2)C2=CC=CC=N2)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. S?rensen E, et al. The selective 5-HT(1A) receptor antagonist p-MPPI antagonizes sleep--waking and behavioural effects of 8-OH-DPAT in rats. Behav Brain Res. 2001 Jun;121(1-2):181-7.2. Cao BJ, et al. Anxiolytic-like profile of p-MPPI, a novel 5HT1A receptor antagonist, in the murine elevated plus-maze. Psychopharmacology (Berl). 1997 Feb;129(4):365-71.
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