p-MPPI hydrochloride

Research use only, not for human use.

p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects.

p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects. pre-treatment with p-MPPI (5 mg/kg intraperitoneal (i.p.)) 30 min before 8-OH-DPAT (0.375 mg/kg subcutaneously (s.c.)) reduced the effect of 8-OH-DPAT on waking and REM sleep.?Also, p-MPPI (5 and 10 mg/kg i.p.) reduced the effect of 8-OH-DPAT on locomotion and partially or completely antagonized hindlimb abduction and flat body posture.?No overt behavioural change was produced by p-MPPI alone.?Thus, p-MPPI behaved as a true 5-HT(1A) antagonist.

p-MPPI hydrochloride has no agonist activity in both in vitro and in vivo tests of pre- and post-synaptic 5-HT1A receptor activity.

p-MPPI hydrochloride (0.5-4.5 mg/kg; i.p.) shows anxiolytic-like profile in the murine elevated plus-maze. Animal Model:Adult male Swiss Webster mice (aged 8-9 weeks) Dosage:0.5, 1.5, 4.5 mg/kg Administration: i.p.Result:Produced a significant and dose-related anxiolytic profile on both conventional (open arm avoidance) and ethological (risk assessment) measures.

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Endocrinology/Hormones

5-HT Receptor

5-HT1A

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220643-77-6

578.87

C25H28ClIN4O2

>98% (HPLC)

In Vitro:?DMSO : 17.86 mg/mL (30.85 mM)

Cl.COC1=CC=CC=C1N1CCN(CCN(C(=O)C2=CC=C(I)C=C2)C2=CC=CC=N2)CC1

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(-20℃)

With Ice Pack

≥ 2 years