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p-MPPI hydrochloride

CAS No. 220643-77-6

p-MPPI hydrochloride( —— )

Catalog No. M22028 CAS No. 220643-77-6

p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    p-MPPI hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects.
  • Description
    p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects. pre-treatment with p-MPPI (5 mg/kg intraperitoneal (i.p.)) 30 min before 8-OH-DPAT (0.375 mg/kg subcutaneously (s.c.)) reduced the effect of 8-OH-DPAT on waking and REM sleep.?Also, p-MPPI (5 and 10 mg/kg i.p.) reduced the effect of 8-OH-DPAT on locomotion and partially or completely antagonized hindlimb abduction and flat body posture.?No overt behavioural change was produced by p-MPPI alone.?Thus, p-MPPI behaved as a true 5-HT(1A) antagonist.
  • In Vitro
    p-MPPI hydrochloride has no agonist activity in both in vitro and in vivo tests of pre- and post-synaptic 5-HT1A receptor activity.
  • In Vivo
    p-MPPI hydrochloride (0.5-4.5 mg/kg; i.p.) shows anxiolytic-like profile in the murine elevated plus-maze. Animal Model:Adult male Swiss Webster mice (aged 8-9 weeks) Dosage:0.5, 1.5, 4.5 mg/kg Administration: i.p.Result:Produced a significant and dose-related anxiolytic profile on both conventional (open arm avoidance) and ethological (risk assessment) measures.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT1A
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    220643-77-6
  • Formula Weight
    578.87
  • Molecular Formula
    C25H28ClIN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 17.86 mg/mL (30.85 mM)
  • SMILES
    Cl.COC1=CC=CC=C1N1CCN(CCN(C(=O)C2=CC=C(I)C=C2)C2=CC=CC=N2)CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. S?rensen E, et al. The selective 5-HT(1A) receptor antagonist p-MPPI antagonizes sleep--waking and behavioural effects of 8-OH-DPAT in rats. Behav Brain Res. 2001 Jun;121(1-2):181-7.2. Cao BJ, et al. Anxiolytic-like profile of p-MPPI, a novel 5HT1A receptor antagonist, in the murine elevated plus-maze. Psychopharmacology (Berl). 1997 Feb;129(4):365-71.
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